Authentic Low-Stakes Practice to Make Meaning Lasting for ELLs: Creating Vocabulary Chants and Songs to Enhance the Word Generation Curriculum

This curriculum creation is designed to supplement the Word Generation (WordGen) vocabulary program for middle school students. It adds songs and chants of the weekly focus words for use as a mnemonic device to remember and synthesize word meaning. The WordGen curriculum is heavily based on reading and writing and English Language Learners (ELLs) are at a disadvantage when tasked with learning and understanding academic vocabulary due to the short length of time for mastery (Cummins, 1999; Collier, 1987; Thompson, 2017). This curriculum is inspired by the desire to appeal to ELLs who would respond favorably to music or kinesthetic modalities in the language classroom. Using music to teach language is found to be a positive way to engage students and facilitate a low-stakes method to learning and practicing language (Bialls, et al., 2021; Chen, 2020l; Landesman Scheckel, 2020; Li & Brand, 2009; Rukholm, 2015). The first two chapters of WordGen have been supplemented with songs and chants/raps for use in ELL and general content classrooms

Keck Spectroscopy of the Gravitational Lens System PG 1115+080: Redshifts of the Lensing Galaxies

The quadruple system PG 1115+080 is the second gravitational lens with a reported measurement of the Hubble constant. In addition to the primary lens, three nearby galaxies are believed to contribute significantly to the lensing potential. In this paper we report accurate redshifts for all four galaxies and show that they belong to a single group at z_d = 0.311. This group has very similar properties to Hickson's compact groups of galaxies found at lower redshifts. We briefly discuss implications for the existing lens models and derive H_0 = 52 +/- 14 km/s/Mpc.Comment: revised to use the updated model of Keeton & Kochanek (astro-ph/9611216) and to correct the velocity dispersion of the group; 10 pages including 2 eps figures and 2 tables. Submitted to the Astronomical Journa

Beginner\u27s Guide to Common Native Bees

Utah is a superb place for beginning bee enthusiasts. Over 1,000 species of native bees exist in Utah (Cane, 2015). Southern Utah alone has approximately the same number of bee species as the entire eastern U.S. coast. There are many reasons for appreciating bees and encouraging their presence in the landscape. Specifically, bees are key to a sustainable environment as they are essential pollinators of food and fiber crops. Bees can also be appreciated for their striking diversity in color and size. This fact sheet highlights the different bee species that you may see in Utah

Assessing neural tuning for object perception in schizophrenia and bipolar disorder with multivariate pattern analysis of fMRI data.

IntroductionDeficits in visual perception are well-established in schizophrenia and are linked to abnormal activity in the lateral occipital complex (LOC). Related deficits may exist in bipolar disorder. LOC contains neurons tuned to object features. It is unknown whether neural tuning in LOC or other visual areas is abnormal in patients, contributing to abnormal perception during visual tasks. This study used multivariate pattern analysis (MVPA) to investigate perceptual tuning for objects in schizophrenia and bipolar disorder.MethodsFifty schizophrenia participants, 51 bipolar disorder participants, and 47 matched healthy controls completed five functional magnetic resonance imaging (fMRI) runs of a perceptual task in which they viewed pictures of four different objects and an outdoor scene. We performed classification analyses designed to assess the distinctiveness of activity corresponding to perception of each stimulus in LOC (a functionally localized region of interest). We also performed similar classification analyses throughout the brain using a searchlight technique. We compared classification accuracy and patterns of classification errors across groups.ResultsStimulus classification accuracy was significantly above chance in all groups in LOC and throughout visual cortex. Classification errors were mostly within-category confusions (e.g., misclassifying one chair as another chair). There were no group differences in classification accuracy or patterns of confusion.ConclusionsThe results show for the first time MVPA can be used successfully to classify individual perceptual stimuli in schizophrenia and bipolar disorder. However, the results do not provide evidence of abnormal neural tuning in schizophrenia and bipolar disorder

The External Shear Acting on Gravitational Lens B 1422+231

In a number of multiply imaged quasar systems, a significant contribution to the lensing potential is provided by groups and clusters of galaxies associated with the primary lens. As part of an ongoing effort to gather observational data on these systems, we present spectroscopy and near-infrared and optical photometry of galaxies in the field of the quadruple lens system B 1422+231. The spectra show that the primary lens and five nearby galaxies belong to a compact group at z = 0.338. The median projected radius of this group is 35 h^{-1} kpc and its velocity dispersion is 550 km/s. A straightforward application of the virial theorem yields a group mass of 1.4 x 10^{13} h^{-1} M(sun), which provides sufficient external shear to produce the observed image configuration. This data rules out a class of models and improves the system's prospects for a measurement of the Hubble constant.Comment: 16 pages including 3 tables, 2 eps figures and 2 jpeg images. Submitted to the Astronomical Journa

Family Participation and Involvement in Early Head Start Home Visiting Services: Relations with Longitudinal Outcomes Executive Summary

Home visiting is an intervention approach used widely to provide individualized services to families living in poverty and children facing risks for poor development. Home visiting programs are often, by design, an indirect means to promote healthy child development and employ a variety of strategies ranging from checking child health and safety to encouraging positive parenting to helping parents access education and employment opportunities. Most home visiting programs, however, state that promoting child development is their overarching goal. Most home visitors work with parents to facilitate “developmental parenting,” a term introduced by Roggman, Boyce, and Innocenti (2008) to describe healthy parent-child interactions likely to support positive outcomes for their children. Promoting developmental parenting captures the overall approach of Early Head Start (EHS) home-based programs (Administration on Children and Families, 2002), the focus of this report

Correlative analyses of RET and RAS mutations in a phase 3 trial of cabozantinib in patients with progressive, metastatic medullary thyroid cancer

BACKGROUND: Cabozantinib significantly prolonged progression-free survival (PFS) versus a placebo in patients with progressive, metastatic medullary thyroid cancer (MTC; P <.001). An exploratory analysis of phase 3 trial data evaluated the influence of rearranged during transfection (RET) and RAS (HRAS, KRAS, and NRAS) mutations on cabozantinib clinical activity. METHODS: Patients (n = 330) were randomized to cabozantinib (140 mg/day) or a placebo. The primary endpoint was PFS. Additional outcome measures included PFS, objective response rates (ORRs), and adverse events in RET and RAS mutation subgroups. RESULTS: Among all study patients, 51.2% were RET mutation–positive (38.2% with RET M918T), 34.8% were RET mutation–unknown, and 13.9% were RET mutation–negative. Sixteen patients were RAS mutation–positive. Cabozantinib appeared to prolong PFS versus the placebo in the RET mutation–positive subgroup (hazard ratio [HR], 0.23; 95% confidence interval [CI], 0.14-0.38; P <.0001), the RET mutation–unknown subgroup (HR, 0.30; 95% CI, 0.16-0.57; P =.0001), and the RAS mutation–positive subgroup (HR, 0.15; 95% CI, 0.02-1.10; P =.0317). The RET M918T subgroup achieved the greatest observed PFS benefit from cabozantinib versus the placebo (HR, 0.15; 95% CI, 0.08-0.28; P <.0001). The ORRs for RET mutation–positive, RET mutation–negative, and RAS mutation–positive patients were 32%, 22%, and 31%, respectively. No PFS benefit was observed in patients lacking both RET and RAS mutations, although the ORR was 21%. The safety profile for all subgroups was similar to that for the overall cabozantinib arm. CONCLUSIONS: These data suggest that cabozantinib provides the greatest clinical benefit to patients with MTC who have RET M918T or RAS mutations. However, a prospective trial is needed to confirm the relation between genetic variation and the response to cabozantinib. Cancer 2016;122:3856–3864. © 2016 American Cancer Society

Attachment Predicts College Students’ Knowledge, Attitudes, and Skills for Working with Infants, Toddlers, and Families

Research Findings:Adults’ attitudes about attachment relationships are central to how they perceive and respond to children. However, little is known about how attachment styles are related to teachers’ attitudes toward and interactions with infants and toddlers. From a survey of 207 students taking early childhood (EC) courses at 4 U.S. universities, we report relations among students’ attachment styles and their (a) career goals, (b) attitudes about caring for and educating infants and young children, and (c) interaction skills for responding in developmentally supportive ways. Overall, attachment security was positively associated with career goals focused on working with younger children, knowledge about infant/toddler development, attitudes that acknowledge the importance of adult support in children’s development, and developmentally supportive interaction skills. Students who scored high on attachment fearfulness minimized the importance of adults in children’s lives, minimized the importance of the early years for later learning, and endorsed strict and controlling forms of child guidance. Practice or Policy: A conceptual mediation model linking a path from attachment to caregiving skill through knowledge and attitudes is articulated. We propose a person-centered pedagogy for infant/toddler professional preparation that provides opportunities for reflection on one’s own attachment and its effects on work with young childre

Plasma-based assays distinguish hyperfibrinolysis and shutdown subgroups in trauma-induced coagulopathy

BACKGROUND Trauma patients with abnormal fibrinolysis have increased morbidity and mortality. Knowledge of mechanisms differentiating fibrinolytic phenotypes is important to optimize treatment. We hypothesized that subjects with abnormal fibrinolysis identified by whole blood viscoelastometry can also be distinguished by plasma thrombin generation, clot structure, fibrin formation, and plasmin generation measurements. METHODS Platelet-poor plasma (PPP) from an observational cross-sectional trauma cohort with fibrinolysis shutdown (% lysis at 30 minutes [LY30] \u3c 0.9, n = 11) or hyperfibrinolysis (LY30 \u3e 3%, n = 9) defined by whole blood thromboelastography were studied. Noninjured control subjects provided comparative samples. Thrombin generation, fibrin structure and formation, and plasmin generation were measured by fluorescence, confocal microscopy, turbidity, and a fluorescence-calibrated plasmin assay, respectively, in the absence/presence of tissue factor or tissue plasminogen activator (tPA). RESULTS Whereas spontaneous thrombin generation was not detected in PPP from control subjects, PPP from hyperfibrinolysis or shutdown patients demonstrated spontaneous thrombin generation, and the lag time was shorter in hyperfibrinolysis versus shutdown. Addition of tissue factor masked this difference but revealed increased thrombin generation in hyperfibrinolysis samples. Compared with shutdown, hyperfibrinolysis PPP formed denser fibrin networks. In the absence of tPA, the fibrin formation rate was faster in shutdown than hyperfibrinolysis, but hyperfibrinolysis clots lysed spontaneously; these differences were masked by addition of tPA. Tissue plasminogen activator–stimulated plasmin generation was similar in hyperfibrinolysis and shutdown samples. Differences in LY30, fibrin structure, and lysis correlated with pH. CONCLUSION This exploratory study using PPP-based assays identified differences in thrombin generation, fibrin formation and structure, and lysis in hyperfibrinolysis and shutdown subgroups. These groups did not differ in their ability to promote tPA-triggered plasmin generation. The ability to characterize these activities in PPP facilitates studies to identify mechanisms that promote adverse outcomes in trauma